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In this work, a novel drug delivery system was introduced based on binary solvent gel in which both hydrophobic and hydrophilic drugs could be loaded into the gel without altering the gelation property of the native system. The gel was simply prepared from native β-cyclodextrin (β-CD) by crystallization-induced self-assembly. Physicochemical and mechanical properties of the gel were systematically...
Just as biological behaviors that can be tuned by salt ions, salt-containing soft materials are of great importance in various fields. Here we report a supramolecular cyclodextrin gel, of which properties including gelation behavior, fiber size, thermal stability as well as mechanical strength could be well tailored by inorganic salts. The concentrations, types of alkali salts were tested and had...
Curcumin is a safe and nontoxic natural potential antitumor drug. However, its extremely low aqueous solubility severely limits its clinical application. We designed a supramolecular curcumin vesicle based on different curcumin-cyclodextrin amphiphiles, which could greatly enhance the aqueous solubility of curcumin up to 7000-fold. The vesicles can exist for about one month in aqueous solution at...
Vesicles directly prepared from cyclodextrin–ftorafur supramolecular amphiphiles were reported. Ftorafur can be efficiently encapsulated in the cyclodextrin cavities embedded in the vesicle membrane. The morphologies and diameters of the vesicles were identified in detail by transmission electron microscopy (TEM), scanning electron microscopy (SEM), atomic force microscopy (AFM) and dynamic light...
Herein, we report a novel responsive assembly system consisting of an amphiphilic drug fenspiride and β-cyclodextrin in host–guest approach. Fenspiride molecules can self-assembled into vesicles in aqueous solution. The obtained vesicles were characterized in detail by transmission electron microscopy (TEM), scanning electron microscopy (SEM) and atomic force microscopy (AFM). Furthermore, such a...
This paper describes an instant-formative organogel triggered by small organic molecules (cogelators) at a high temperature. The system was prepared by β-cyclodextrin (β-CD) and lithium chloride (LiCl) in N, N-dimethyl acetamide (DMAc). Under stirring, a clear solution is obtained at 120–130°C and transformed into a gel phase within several seconds once the cogelators are injected. The gelling times...
A novel supramolecular organogel consisting of β-cyclodextrin (β-CD), 4,4′-isopropylidendiphenol (BPA), LiCl, N,N-dimethylformamide (DMF) and ethanol (EtOH) was prepared. The system without EtOH was a clear solution at ambient temperature and turned into an organogel upon the addition of ethanol (EtOH). The micro-morphologies of the organogel were various, such as ellipsoids, spheres, cuboids and...
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