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BACKGROUNDProstate cancer cells must maintain or achieve the further ability of proliferation during the progression. The molecular mechanisms, however, remain poorly understood. We identified a novel oncogene, termed membrane‐spanning 4‐domains, subfamily A, member 8B (MS4A8B), over‐expressed in prostate cancer.
METHODSWe firstly detected MS4A8B mRNA in 13 types of paired human normal and cancer...
BACKGROUNDMultiplex urine‐based assay emerged outperforms single biomarker (e.g., prostate‐specific antigen, PSA) for predicting prostate cancer (CaP), whereas its combined mode has to be fully optimized. Our aim is to determine whether a strategy of combining gene‐based, protein‐based, metabolite‐based with positive, negative makers in urine could optimize a multiplex model for detecting CaP.
METHODSUsing...
BACKGROUNDmiR‐21 has been recognized as an “onco‐microRNA” with the activity of negatively modulating the expression of tumor‐suppressor genes. However, its role in prostate cancer (CaP) has not been well‐documented. We designed this study to assess the potential function of serum miR‐21 in the progression of CaP.
METHODSSerum samples of 56 patients, including 20 patients with localized CaP, 20 with...
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