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Studies suggest that IL-1β (encoded by IL-1B gene) is a pro-inflammatory cytokine and potent inhibitor of gastric acid secretion, which is proposed as a key determinant in gastric carcinogenesis. Two potentially functional polymorphisms (C−31T and T−511C) in the IL-1B promoter were suggested to be correlated with alteration of Helicobacter pylori infection and IL-1β expression and therefore may be...
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