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One of the most important research areas in case–control Genome‐Wide Association Studies is to determine how the effect of a genotype varies across the environment or to measure the gene–environment interaction (G × E). We consider the scenario when some of the “healthy” controls actually have the disease and when the frequency of these latent cases varies by the environmental variable of interest...
Single‐variant‐based genome‐wide association studies have successfully detected many genetic variants that are associated with a number of complex traits. However, their power is limited due to weak marginal signals and ignoring potential complex interactions among genetic variants. The set‐based strategy was proposed to provide a remedy where multiple genetic variants in a given set (e.g., gene or...
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