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There is much interest in identifying novel pharmacotherapeutic targets that improve clinical outcomes for the treatment of alcohol use disorder (AUD). One promising target for therapeutic intervention is the relaxin family peptide 3 (RXFP3) receptor, a cognate receptor for neuropeptide relaxin‐3, which has previously been implicated in regulating alcohol drinking behavior. Recently, we developed...
There is growing evidence that immune signalling may be involved in both the causes and consequences of alcohol abuse. Toll‐like receptor (TLR) expression is increased by alcohol consumption and is implicated in AUD, and specifically TLR7 may play an important role in ethanol consumption. We administered the TLR7‐specific agonist imiquimod in male and female Long–Evans rats to determine (1) gene expression...
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