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The Sigma 1 receptor (SIGMAR1) is a transmembrane protein located in the mitochondria‐associated endoplasmic reticulum membrane, and plays an important role in cell survival as a pluripotent modulator of a variety of signaling pathways related to neurodegeneration. Though SIGMAR1 is a potential target for neurodegenerative diseases, the specific role of SIGMAR1 in different tissue and cell types remains...
LHX4 is a LIM‐homeodomain transcription factor essential for the development of spinal cord and pituitary gland. Mice with homozygous Lhx4‐null mutation suffer early postnatal death from lung defect. In this study, to facilitate the research on Lhx4 function, we designed a targeting construct to generate two novel Lhx4 mouse lines: Lhx4loxP conditional knockout and Lhx4tdT reporter knock‐in mice...
Tissue‐specific inducible Cre recombinase mouse lines allow precise genetic manipulations in spatiotemporal manners and are pivotal for functional studies of genes during development and in adults. Growth factor independence 1 (GFI1) is an essential transcription factor expressed in the hair cells of mouse inner ear and Gfi1 locus serves as an excellent anchor site to drive the expression of inducible...
LHX3, a LIM‐homeodomain transcription factor, is broadly expressed in the developing pituitary, spinal cord, medulla, retina and inner ear, and plays essential roles during embryonic development. Mice with homozygous Lhx3 null mutation exhibit failure in the formation of pituitary gland and die perinatally. To facilitate the functional study of Lhx3 in mice, we engineered and characterized two novel...
LHX9 is a LIM‐homeodomain transcription factor essential for the development of gonads, spinal cord interneurons, and thalamic neurons to name a few. We recently reported the expression of LHX9 in retinal amacrine cells during development. In this study, we generated an Lhx9‐GFPCreERT2 (GCE) knock‐in mouse line by knocking‐in a GCE cassette at the Lhx9 locus, thus inactivating endogenous Lhx9. Lhx9...
Gfi1 encodes a zinc‐finger transcription factor essential for the development and maintenance of haematopoiesis and the inner ear. In mouse inner ear, Gfi1 expression is confined to hair cells during development and in adulthood. To construct a genetic tool for inner ear hair cell‐specific gene deletion, we generated a Gfi1‐Cre mouse line by knocking‐in Cre coding sequences into the Gfi1 locus and...
Atoh1 encodes a basic helix‐loop‐helix (bHLH) transcription factor required for the development of the inner ear sensory epithelia, the dorsal spinal cord, brainstem, cerebellum, and intestinal secretory cells. In this study, to create a genetic tool for the research on gene function in the ear sensory organs, we generated an Atoh1‐Cre knock‐in mouse line by replacing the entire Atoh1 coding sequences...
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