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A sequential “turn-off” surface enhance Raman scattering (SERS) assay platform for the detection of protein arginine kinase McsB is constructed based on arginine N-phosphorylation process. The positive charged peptide initiates the aggregation of labelled Au nanoparticles (AuNPs) to form ‘‘Hot Spots’’, resulting to a higher SERS intensity. However, the aggregation of AuNPs could also be disbanded...
Transferrin (TrF) is an important glycoprotein and disease biomarker that controls iron ion balance in the human body. Isolation and detection of TrF have important implication for the early detection of disease. Thus, a magnetic fluorescent molecularly imprinted nanoparticles (FMINPs) was prepared for extraction and fluorescence detection of TrF. The FMINPs was prepared with two steps, the first...
Lung cancer is the leading cause of cancer-related deaths worldwide, and approximately 85% are diagnosed as non-small-cell lung cancer (NSCLC). However, efficient detection and diagnosis of NSCLC at early stage is still challenging. In this work, we developed a simple, ultrasensitive and high selective strategy for A549 human NSCLC cells detection based on combining the reorganization property of...
In the present study, magnetic nanoparticles (MNPs) with phenyl functionalized core and a hydrophilic methylcellulose coating were synthesized. The functionalized MNPs showed excellent dispersibility in aqueous solution and they were applied to magnetic solid phase extraction (MSPE) of sildenafil and its metabolite, desmethyl sildenafil, from human urine and plasma samples followed by high performance...
Electromembrane extraction (EME) as a novel sample preparation technique was firstly applied for the purification and enrichment of four polyamines mainly present in saliva samples. These four target analytes, putrescine, cadaverine, spermidine, and spermine, were directly determined by CZE with capacitively coupled contactless conductivity detection (CZE-C 4 D) after EME procedure. Several...
Hexanal (Hex) and heptanal (Hep) in human blood have been regarded as potential biomarkers of lung cancer. In this work, a hollow-fiber liquid-phase microextraction (HF-LPME) method has been developed for the preconcentration of these trace aldehydes in urine samples. After derivatization with an electroactive compound 2-thiobarbituric acid, these two non-electroactive aldehydes were converted to...
A novel molecularly imprinted photonic polymer (MIPP) using maleic anhydride modified β-cyclodextrin (β-CD) and acrylic acid as functional monomers has been presented for amino acid sensing. Reactive β-CD monomer carrying vinyl carboxylic acid functional groups was first synthesized. MIPP was fabricated by filling precursor solution into the interstitial spaces of polystyrene photonic crystal templates,...
A rapid and simple enrichment system was developed on microfluidic chip which was integrated with on-line complexing and fluorescence detection. Microparticles of ion-exchange resin were trapped into the microchannel by a fabricated weir-structure in the end of the microchannel to construct a micro-solid-phase extraction (μ-SPE) device. Some commonly existing metal ions in environment were served...
High throughput analysis of sunscreen agents present in cream cosmetic has been demonstrated, typically 2 samples per minute, using neutral desorption extractive electrospray ionization mass spectrometry (ND-EESI-MS) without sample pretreatment. For the targeted compounds such as 4-Aminobenzoic acid and oxybenzone, ND-EESI-MS method provided linear signal responses in the range of 1–100ppb. Limits...
The principal components, isoflavonoids and astragalosides, in the extract of Radix Astragali were detected by a high-performance liquid chromatography couple to electrospray ionization ion trap multiple-stage tandem mass spectrometry (HPLC-ESI-IT-MS n ) method. By comparing the retention time (t R ) of HPLC, the ESI-MS n data and the structures of analyzed compounds with the...
Monodisperse magnetic C 18 microspheres were prepared based on the three-step reactions of solvothermal reduction, silanization and alkylation. The microspheres are of uniform sizes in the range of 200–260nm. The structure of synthesized magnetic C 18 microspheres was studied by transmission electron microscopy, scanning electron microscopy, X-ray diffraction patterns, element analysis...
CdTe@SiO 2 fluorescent particles were synthesized via hydrolysis and condensation of tetraethyl orthosilicate (TEOS) in water-in-oil (W/O) emulsion. Uniform luminophore-doped silica nanoparticles with 100nm in diameter were obtained using microemulsion method and characterized by SEM. Antibody proteins were successfully conjugated to the fluorescent particles by the reaction of avidin and...
A novel method for the determination of 6-mercaptopurine (6MP) has been developed based on fluorescence enhancement of Au nanoparticles (AuNPs). The fluorescent AuNPs with mean diameter of ∼15nm were synthesized in aqueous solution, exhibiting the stable maximum emission at 367nm, under the excitation at wavelength of 264nm. The AuNPs self-assembly with 6MP were characterized with transmission electron...
Nanometer titanium dioxide immobilized on silica gel (immobilized nanometer TiO 2 ) was prepared by sol–gel method and characterized by using X-ray diffraction (XRD) and scanning electron microscope (SEM). The adsorptive potential of immobilized nanometer TiO 2 for the preconcentration of trace Cd, Cr, Cu and Mn was assessed in this work. The metal ions studied can be quantitative...
The interactions between drug molecules and membrane were studied using the new chromatography stationary phase of liposome coated zirconia–magnesia. logK s (ZrO 2 –MgO) on this new chromatography for some drugs, compared with that on liposome coated silica chromatography and other reported data, fair correlations were observed between them when excluding effect of special adsorption...
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