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Protein toxins produced by bacteria are the cause of many life‐threatening diarrheal diseases. Many of these toxins, including cholera toxin (CT), enter the cell by first binding to glycolipids in the cell membrane. Inhibiting these multivalent protein/carbohydrate interactions would prevent the toxin from entering cells and causing diarrhea. Here we demonstrate that the site‐specific modification...
Die B‐Untereinheit des Choleratoxins wurde zu einem wirksamen Inhibitor des Ausgangstoxins umgewandelt. Die Hemmung der Toxinadhäsion gelang W. B Turnbull und Mitarbeitern in ihrer Zuschrift auf S. 8463 ff. durch eine nichtbindende Mutante der B‐Untereinheit, die mit fünf Kopien der Kohlenhydratliganden modifiziert wurde. Die ortsspezifische Modifizierung eines Proteingerüsts, das in Größe und Valenz...
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