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Anticancer drug resistance demands innovative approaches that boost the activity of drugs against drug‐resistant cancers without increasing the systemic toxicity. Here we show the use of enzyme‐instructed self‐assembly (EISA) to generate intracellular supramolecular assemblies that drastically boost the activity of cisplatin against drug‐resistant ovarian cancer cells. We design and synthesize small...
The review describes the use of enzyme catalysis and self‐assembly, two essential and ubiquitous processes in biology, to create molecular nanofibers of peptide derivatives at the supramolecular level as potential nanomedicines and biomaterials. In particular, we discuss the use of enzymes to instruct the self‐assembly of small peptide derivatives for hydrogelation, which takes place in vitro or in vivo...
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