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4-Aryl-5-cyano-2H-1,2,3-triazoles bearing a variety of substituting groups on 4-phenyl were synthesized. The chemicals, designed as HER2 tyrosine kinase inhibitors, were screened for bioactivity of inhibiting growth of breast cancer MDA-MB-453 cells. The lowest IC 50 value of inhibiting HER2 tyrosine kinase phosphorylation in breast cancer cells is 6.6μM and the IC 50 value of cell...
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