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We previously found that CD8 T cells from IFN-γ gene knockout (GKO) donors induce more severe lethal GVHD compared with CD8 T cells from wild-type (WT) donors in fully MHC-mismatched strain combinations. In this study, we investigated the mechanisms by which IFN-γ inhibits GVHD in a parent → F1 (B6 → B6D2F1) allogeneic HCT (allo-HCT) model. IFN-γ was strongly protective against GVHD in this parent...
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