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It is well known that obesity‐induced white adipose tissue inflammation is an important reason for insulin‐resistance and type 2 diabetes mellitus. Sirtuin‐1 (SIRT1) is an important regulator of inflammtion response pathways in white adipose tissue. Here, we found that miR‐221 negatively regulated SIRT1 in white adipose tissue during inflammation and HFD‐induced obesity. MiR‐221 is a putative oncogene...
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