Search results for: Harald Gröger

Items from 1 to 20 out of 96 results

article

Merging MOF Chemistry & Biocatalysis: A Perspective for Achieving Efficient Organic Synthetic Processes and Applications in the Chemical Industry?

Harald Gröger, Adil Allahverdiyev, Jianing Yang, Johannes Stiehm

Advanced Functional Materials > 34 > 43 > n/a - n/a

Biocatalysis has emerged in recent decades toward a widely applied catalysis technology in the chemical industry. In particular the fine chemicals and pharmaceuticals industries benefit from the advantages of biocatalysis, which made its way to a dominating industrial core technology for manufacturing chiral molecules. However, often biocatalysis is still to a certain extent away from having solved...

article

Increased Readiness for Water Splitting: NiO‐Induced Weakening of Bonds in Water Molecules as Possible Cause of Ultra‐Low Oxygen Evolution Potential

Tom Bookholt, Xian Qin, Bettina Lilli, Dirk Enke, more

Small > 20 > 30 > n/a - n/a

The development of non‐precious metal‐based electrodes that actively and stably support the oxygen evolution reaction (OER) in water electrolysis systems remains a challenge, especially at low pH levels. The recently published study has conclusively shown that the addition of haematite to H₂SO₄ is a highly effective method of significantly reducing oxygen evolution overpotential and extending anode...

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Merging High‐Pressure Syngas Metal Catalysis and Biocatalysis in Tandem One‐Pot Processes for the Synthesis of Nonchiral and Chiral Alcohols from Alkenes in Water

Hannah Bork, Kim E. Naße, Andreas J. Vorholt, Harald Gröger

Angewandte Chemie International Edition > 63 > 28 > n/a - n/a

While simultaneously proceeding reactions are among the most fascinating features of biosynthesis, this concept of tandem processes also offers high potential in the chemical industry in terms of less waste production and improved process efficiency and sustainability. Although examples of one‐pot chemoenzymatic syntheses exist, the combination of completely different reaction types is rare. Herein,...

article

Verknüpfung von Hochdruck‐Synthesegas‐Metallkatalyse und Biokatalyse in Tandem‐Eintopf‐Verfahren für die Synthese nicht‐chiraler und chiraler Alkohole aus Alkenen in Wasser

Hannah Bork, Kim E. Naße, Andreas J. Vorholt, Harald Gröger

Angewandte Chemie > 136 > 28 > n/a - n/a

Während simultan ablaufende Reaktionen zu den faszinierendsten Merkmalen der Biosynthese gehören, bietet dieses Konzept der Tandemprozesse auch ein großes Potenzial für die chemische Industrie im Hinblick auf eine geringere Abfallproduktion und eine verbesserte Prozesseffizienz und Nachhaltigkeit. Obwohl es Beispiele für chemoenzymatische Eintopf‐Synthesen gibt, ist die Kombination völlig unterschiedlicher...

article

Strategies to Design Chemocatalytic Racemization of Tertiary Alcohols: State of the Art & Utilization for Dynamic Kinetic Resolution

Harald Gröger, Satoshi Horino, Kyohei Kanomata, Shuji Akai

Chemistry – A European Journal > 30 > 36 > n/a - n/a

The synthesis of enantiomerically pure tertiary alcohols is an important issue in organic synthesis of a range of pharmaceuticals including molecules such as the anti‐HIV drug Efavirenz. A conceptually elegant approach to such enantiomers is the dynamic kinetic resolution of racemic tertiary alcohols, which, however, requires efficient racemization strategies. The racemization of tertiary alcohols...

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Front Cover: Kinetic Resolution of Cyclic Tertiary Alcohols with Lipase A from Candida Antarctica (Eur. J. Org. Chem. 21/2024)

Satoshi Horino, Karla Wagner, Anke Hummel, Kyohei Kanomata, more

European Journal of Organic Chemistry > 27 > 21 > n/a - n/a

The Front Cover's dandelion represents the lipase‐catalyzed kinetic resolution of racemic tertiary alcohols. The fluff is deemed a serine residue, bearing an acyl moiety, at the active center of an acyl‐enzyme intermediate. When R‐alcohols on the spring breeze come into contact with the active center, they are converted to the corresponding esters and fly away on the wind, just like dandelion seeds...

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Kinetic Resolution of Cyclic Tertiary Alcohols with Lipase A from Candida Antarctica

Satoshi Horino, Karla Wagner, Anke Hummel, Kyohei Kanomata, more

European Journal of Organic Chemistry > 27 > 21 > n/a - n/a

Enzyme‐catalyzed acylative kinetic resolution (KR) and dynamic kinetic resolution (DKR) of racemic primary and secondary alcohols have been widely reported to produce esters with high enantiomeric purity. In contrast, similar KRs of tertiary alcohols have been reported for only a limited range of substrates and require prolonged reaction times of several days. To gain deeper insight into the substrate...

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Design of 3D‐Printed Heterogeneous Reactor Systems To Overcome Incompatibility Hurdles when Combining Metal and Enzyme Catalysis in a One‐Pot Process

Nadiya Salitra, Jonas Gurauskis, Harald Gröger

Angewandte Chemie International Edition > 63 > 24 > n/a - n/a

Combining chemo‐ and biocatalysis enables the design of novel economic and sustainable one‐pot processes for the preparation of industrial chemicals, preferably proceeding in water. While a range of proofs‐of‐concept for the compatibility of such catalysts from these two different “worlds of catalysis” have recently been demonstrated, merging noncompatible chemo‐ and biocatalysts for joint applications...

article

Design von 3D‐gedruckten heterogenen Reaktorsystemen zur Überwindung von Inkompatibilitätshürden bei der Kombination von Metall‐ und Enzym‐Katalyse in einem Eintopf‐Prozess

Nadiya Salitra, Jonas Gurauskis, Harald Gröger

Angewandte Chemie > 136 > 24 > n/a - n/a

Die Kombination von Chemo‐ und Biokatalyse ermöglicht die Entwicklung neuartiger ökonomischer und nachhaltiger Eintopfverfahren für die Herstellung von Industriechemikalien, welche vorzugsweise in Wasser ablaufen. Während kürzlich anhand einer Reihe von Beispielen der Nachweis für die Kompatibilität solcher Katalysatoren aus diesen beiden unterschiedlichen “Welten der Katalyse” aufgezeigt wurde, blieb...

article

Overcoming Thermodynamically Driven Retro‐Diels–Alder Reaction through a Cascade One‐Pot Process Exemplified for a Bio‐Based Platform Chemical

Bastian Altemeier, Harald Gröger

European Journal of Organic Chemistry > 26 > 21 > n/a - n/a

In this contribution, we describe a new approach to apply thermodynamically unfavored reactions in synthetic chemistry and to integrate them in cascade processes. By means of a new developed procedure for multi‐step one‐pot syntheses, we succeeded in nearly completely converting a thermodynamically labile Diels–Alder adduct, which strongly tends to react back, to the target product with high conversion...

article

Rational Biocatalyst Design for a Cyanide‐Free Synthesis of Long‐Chain Fatty Nitriles from Their Aldoximes

Hilmi Yavuzer, Jianing Yang, Harald Gröger

European Journal of Lipid Science and Technology > 125 > 5 > n/a - n/a

Recently, the capability of the aldoxime dehydratase from Bacillus sp. (OxdB) for the transformation of fatty aldoximes into fatty nitriles with impressive substrate loadings is reported. However, the substrate scope of this biocatalyst turned out to be limited in terms of the chain length with decanal oxime being the substrate with the longest well tolerated n‐alkyl chain. Besides the increased bulkiness...

article

Combination of Asymmetric Organo‐ and Biocatalysis in Flow Processes and Comparison with their Analogous Batch Syntheses

Lukas Schober, Fabio Tonin, Ulf Hanefeld, Harald Gröger

European Journal of Organic Chemistry > 2022 > 7 > n/a - n/a

A sequential‐type as well as a tandem‐type chemoenzymatic flow cascade combining an organocatalytic aldol reaction and a biocatalytic reduction to form stereoselectively a 1,3‐diol with two stereogenic centers were developed. Initially, a comprehensive screening of 24 alcohol dehydrogenases was carried out and the identified candidates were applied in different multi‐step flow cascades. All four stereoisomers...

article

Structure‐Performance Guided Design of Sustainable Plasticizers from Biorenewable Feedstocks

Carmen Plass, Niklas Adebar, Robert Hiessl, Joscha Kleber, more

European Journal of Organic Chemistry > 2021 > 45 > 6086 - 6096

The search for more sustainable solutions for plastics production, moving away from petrochemical feedstocks as today's major raw material basis, is a research area of increasing interest. This task goes far beyond the issue of designing greener polymers and their related monomers as tailor‐made plastics require, besides the polymer itself, further components. These additives also need to be switched...

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Front Cover: Structure‐Performance Guided Design of Sustainable Plasticizers from Biorenewable Feedstocks (Eur. J. Org. Chem. 45/2021)

Carmen Plass, Niklas Adebar, Robert Hiessl, Joscha Kleber, more

European Journal of Organic Chemistry > 2021 > 45 > 6084 - 6084

The Front Cover illustrates a concept to switch the raw material basis for plasticizer production from fossil to bio‐based feedstocks. The bicyclic plasticizers, which were synthesized as target molecules, are accessible from bio‐based 2‐methylfuran, maleic anhydride and 2‐ethylhexanol. Evaluating the performance of this new bio‐based plasticizer generation revealed promising plasticizing properties...

article

Rationalizing the Unprecedented Stereochemistry of an Enzymatic Nitrile Synthesis through a Combined Computational and Experimental Approach

Hilmi Yavuzer, Yasuhisa Asano, Harald Gröger

Angewandte Chemie International Edition > 60 > 35 > 19162 - 19168

In this contribution, the unique and unprecedented stereochemical phenomenon of an aldoxime dehydratase‐catalyzed enantioselective dehydration of racemic E‐ and Z‐aldoximes with selective formation of both enantiomeric forms of a chiral nitrile is rationalized by means of molecular modelling, comprising in silico mutations and docking studies. This theoretical investigation gave detailed insight into...

article

Rationalizing the Unprecedented Stereochemistry of an Enzymatic Nitrile Synthesis through a Combined Computational and Experimental Approach

Hilmi Yavuzer, Yasuhisa Asano, Harald Gröger

Angewandte Chemie > 133 > 35 > 19311 - 19317

article

Segmentierte Flow‐Prozesse zur Überwindung von Limitierungen der Ganzzell‐Biokatalyse in Gegenwart von organischen Lösungsmitteln

Niklas Adebar, Alina Nastke, Jana Löwe, Harald Gröger

Angewandte Chemie > 133 > 29 > 15997 - 16004

In der modernen Prozessentwicklung spielt Biokatalyse eine immer gewichtigere Rolle, wobei die Benutzung von Ganzzellkatalysatoren häufig eine bevorzugte Form dieser Biokatalysatoren darstellt. Die Anwendung von Ganzzellkatalysatoren in organischen zweiphasigen Batch‐Synthesen ist jedoch oft durch Einschränkungen im Hinblick auf Stofftransfer, Emulsionsbildung, aufwändiger Aufarbeitung und damit verbundenen...

article

Segmented Flow Processes to Overcome Hurdles of Whole‐Cell Biocatalysis in the Presence of Organic Solvents

Niklas Adebar, Alina Nastke, Jana Löwe, Harald Gröger

Angewandte Chemie International Edition > 60 > 29 > 15863 - 15869

In modern process development, it is imperative to consider biocatalysis, and whole‐cell catalysts often represent a favored form of such catalysts. However, the application of whole‐cell catalysis in typical organic batch two‐phase synthesis often struggles due to mass transfer limitations, emulsion formation, tedious work‐up and, thus, low yields. Herein, we demonstrate that utilizing segmented...

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Frontispiece: Synthetic Processes toward Nitriles without the Use of Cyanide: A Biocatalytic Concept Based on Dehydration of Aldoximes in Water

Alessa Hinzmann, Tobias Betke, Yasuhisa Asano, Harald Gröger

Chemistry – A European Journal > 27 > 17 > n/a - n/a

Nitriles represent a class of compound that still raises challenges in terms of an efficient, cost‐effective, general and, at the same time, sustainable way for their synthesis. Complementing existing chemical routes, recently a cyanide‐free enzymatic process technology based on the use of an aldoxime dehydratase (Oxd) as a biocatalyst component has been developed and successfully applied for the...

article

Synthetic Processes toward Nitriles without the Use of Cyanide: A Biocatalytic Concept Based on Dehydration of Aldoximes in Water

Alessa Hinzmann, Tobias Betke, Yasuhisa Asano, Harald Gröger

Chemistry – A European Journal > 27 > 17 > 5313 - 5321

While belonging to the most fundamental functional groups, nitriles represent a class of compound that still raises challenges in terms of an efficient, cost‐effective, general and, at the same time, sustainable way for their synthesis. Complementing existing chemical routes, recently a cyanide‐free enzymatic process technology based on the use of an aldoxime dehydratase (Oxd) as a biocatalyst component...

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INFONA - science communication portal

Search results for: Harald Gröger

Merging MOF Chemistry & Biocatalysis: A Perspective for Achieving Efficient Organic Synthetic Processes and Applications in the Chemical Industry?

Increased Readiness for Water Splitting: NiO‐Induced Weakening of Bonds in Water Molecules as Possible Cause of Ultra‐Low Oxygen Evolution Potential

Merging High‐Pressure Syngas Metal Catalysis and Biocatalysis in Tandem One‐Pot Processes for the Synthesis of Nonchiral and Chiral Alcohols from Alkenes in Water

Verknüpfung von Hochdruck‐Synthesegas‐Metallkatalyse und Biokatalyse in Tandem‐Eintopf‐Verfahren für die Synthese nicht‐chiraler und chiraler Alkohole aus Alkenen in Wasser

Strategies to Design Chemocatalytic Racemization of Tertiary Alcohols: State of the Art & Utilization for Dynamic Kinetic Resolution

Front Cover: Kinetic Resolution of Cyclic Tertiary Alcohols with Lipase A from Candida Antarctica (Eur. J. Org. Chem. 21/2024)

Kinetic Resolution of Cyclic Tertiary Alcohols with Lipase A from Candida Antarctica

Design of 3D‐Printed Heterogeneous Reactor Systems To Overcome Incompatibility Hurdles when Combining Metal and Enzyme Catalysis in a One‐Pot Process

Design von 3D‐gedruckten heterogenen Reaktorsystemen zur Überwindung von Inkompatibilitätshürden bei der Kombination von Metall‐ und Enzym‐Katalyse in einem Eintopf‐Prozess

Overcoming Thermodynamically Driven Retro‐Diels–Alder Reaction through a Cascade One‐Pot Process Exemplified for a Bio‐Based Platform Chemical

Rational Biocatalyst Design for a Cyanide‐Free Synthesis of Long‐Chain Fatty Nitriles from Their Aldoximes

Combination of Asymmetric Organo‐ and Biocatalysis in Flow Processes and Comparison with their Analogous Batch Syntheses

Structure‐Performance Guided Design of Sustainable Plasticizers from Biorenewable Feedstocks

Front Cover: Structure‐Performance Guided Design of Sustainable Plasticizers from Biorenewable Feedstocks (Eur. J. Org. Chem. 45/2021)

Rationalizing the Unprecedented Stereochemistry of an Enzymatic Nitrile Synthesis through a Combined Computational and Experimental Approach

Rationalizing the Unprecedented Stereochemistry of an Enzymatic Nitrile Synthesis through a Combined Computational and Experimental Approach

Segmentierte Flow‐Prozesse zur Überwindung von Limitierungen der Ganzzell‐Biokatalyse in Gegenwart von organischen Lösungsmitteln

Segmented Flow Processes to Overcome Hurdles of Whole‐Cell Biocatalysis in the Presence of Organic Solvents

Frontispiece: Synthetic Processes toward Nitriles without the Use of Cyanide: A Biocatalytic Concept Based on Dehydration of Aldoximes in Water

Synthetic Processes toward Nitriles without the Use of Cyanide: A Biocatalytic Concept Based on Dehydration of Aldoximes in Water

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