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This result, for the first time, demonstrates that under swine interferon-β (swIFN-β) immune pressure molecular variation of porcine reproductive and respiratory syndrome virus (PRRSV) accelerates. PRRSV-A1 strain was continuously propagated in Marc-145 cells primed with swIFN-β for 20 passages to develop RRRSV-A1βf 20 strains while PRRSV-A1f 20 was control without swIFN-β respectively...
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