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Ancestry informative markers play an important role in medical genetics and forensic analyses. Several ancestry informative SNP panels have been developed and validated that can differentiate global populations into continental or major regional groups. These global panels have served as good first‐tier genetic markers; however, their performance in discriminating populations within regions appears...
Association studies that genotype affected offspring and their parents (triads) offer robustness to genetic population structure while enabling assessments of maternal effects, parent‐of‐origin effects, and gene‐by‐environment interaction. We propose case‐parents designs that use pooled DNA specimens to make economical use of limited available specimens. One can markedly reduce the number of genotyping...
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