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A novel dead-end affinity filtration system is presented for the enrichment of circulating tumor cells (CTCs) from whole blood with high efficiency, selectivity and throughput. At the heart of the system lies an affinity membrane, which was prepared by chemical surface modification of a commercial micro-filter to exclusively allow for the specific adhesion of CTCs. First filtration experiments showed...
We describe a novel method to extract magnetic particles from plugs in plug-based microfluidic devices. In general, the extraction of particles from plugs is difficult as the high surface energy of an aqueous phase dispersed in a non-polar carrier liquid usually prevents the penetration of particles through this interface. Key to our approach is to achieve particle extraction by generating channel...
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