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Effects of different solvents including methanol, ethanol, and n-butylalcohol on the crystallization of avermectin B1a were studied in this paper. In pure crystallization system, solvent effects on nucleation rate and crystal morphology were studied by varying relative supersaturation ratio, which was 1.3–2.8 for methanol, 1.8–2.8 for ethanol, and 2.8–4.5 for n-butylalcohol respectively. Results showed...
Impurities cannot readily be removed during crystallization of avermectin B1a. This study aims to investigate the main impurity effects on the crystallization of avermectin B1a. Impurities, A1a, A2a, B2a and saccharides, were isolated from avermectins crude powder by adsorption column chromatography. Impurity effects on nucleation rate, crystal morphology, and purity of crystals were studied by varying...
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