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In the human mechanosensation system, rapidly adapting afferents project sensory signals of flutter (5–50Hz) to the contralateral primary somatosensory cortex (S1) and bilateral secondary somatosensory cortex (S2) whereas Pacinian afferents project sensory signals of vibration (50–400Hz) to bilateral S2. However, it remains largely unknown how somatosensory cortical activity changes as a function...
Background: Adrenergic α2a receptors (ADRA2A) are expressed in the central nervous system and peripheral tissues. The primary mechanism of action of mirtazapine is the antagonism of central presynaptic α2 receptors. Mirtazapine is reportedly associated with weight gain. Our objective was to determine whether the ADRA2A −1291C/G polymorphism is associated with weight gain and treatment response to...
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