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This study presents evidence for the role of spectrin and the anion exchanger in the temperature activation of ion permeability, hyperthermic permeability transition (HPT), involved in thermal necrosis of RBCs. Membranes, undergoing HTP at conditions sparing the structure of spectrin (39°C, 18%, v/v ethanol, 3min), became irreversibly permeabilized for NaCl but retained impermeability for sucrose...
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