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Exercise, especially anaerobic one, can gradually increase muscle mass over time as a result of adaptive responses of muscle cells to ensure metabolic homeostasis in the tissue. Low‐level light therapy (LLLT) or photobiomodulation exhibits beneficial effects on promoting muscular functions, regeneration, and recovery from exhausting exercise, although the underlying cellular mechanisms remain poorly...
Exhausting exercise results in hypoxia in muscle cells and impedes myotube differentiation from myoblasts, a process involving active biogenesis of nuclei and mitochondria. The impediment was however substantially mitigated by pretreatment of myoblasts with low‐level light therapy (Pre‐LLL). Pre‐LLL, but not post‐LLL, significantly enhanced glucose uptake, prevented energy metabolic switch from oxidative...