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Introduction: Acquired immunodeficiency syndrome (AIDS) and malaria are two diseases that are a significant cause of human morbidity and mortality in large areas of the world and to which efficient vaccines are still awaited. Although the correlates of protection remain elusive, it is likely that cytotoxic T lymphocytes (CTL) play an important role in the control of these infections. Development...
Introduction: Modified Virus Ankara (MVA) is an attenuated strain of vaccinia virus derived by serial passage through chick embryos > 570 times by Professor A. Mayr. MVA was administered to > 120,000 individuals towards the end of the smallpox eradication campaign without any significant adverse side effects. We have sought to establish the reasons for the safety and immunogenicity of this...
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