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The four isoforms of desmosomal cadherin desmogleins (Dsg1–4) are expressed in epithelial tissues in a differentiation-specific manner. Extensive sequencing of the human genome has revealed only one copy of the Dsg1 gene. However, we recently cloned two novel additional mouse Dsg1 genes, Dsg1-β and -γ, which flank the original Dsg1-α on chromosome 18. Sequence conservation between the Dsg1 isoforms...
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