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T lymphocytes expressing NK1.1 marker (NKT) have been suggested to play crucial roles in immune modulation.Aim.– To determine the role of NK1.1+ cells in induction and maintenance of pro-inflammatory and/or tolerizing responses.Methods.– Colitis was induced in C57/B6 donor mice by intracolonic instillation of trinitrobenzenesulfonic acid (TNBS). Donor mice received five oral doses of colonic proteins...
Oral tolerance is the induction of immune hyporesponsiveness to orally administered antigens. It was described in association with a decrease in interferon gamma (IFNγ) production by activated T cells. To determine the role of IFNγ and IL10 in immunemodulation via oral tolerization. Colitis was induced by intracolonic instillation of trinitrobenzene sulfonic acid. Treated mice received five oral doses...
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