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The Support Vector Machine method has a good learning and generalization ability. Unfortunately, there are no comprehensive theories to guide the parameter selection of the SVM, which largely limits its application. In order to get the optimal parameters automatically, researchers have tried a variety of methods. Using genetic algorithms to optimize parameters of an SVM Classifier has become one of...
An epitope activates B cells to amplify and induce antibodies which can neutralize the foreign molecules, particles and pathogens. It also plays a crucial role in developing synthetic peptides for vaccination. Identification of epitopes using biological screening approaches is time consuming and high cost. Therefore, bioinformatics approaches are developed to enhance the speed of identifying the epitopes...
B-cell epitopes play an important role for developing synthetic peptide vaccines and inducing antibody responses. Applying biological experiments for epitope identification is time consuming and demands a lot of experimental resources. Nevertheless, it is important yet challenging task for designing a computer-aided B-cell linear epitope prediction system with high precision rates. In this paper,...
Bacterial meningitis is still a life-threatening disease, and early diagnosis of pathogen can be crucial to improving survival rate. Using the surface-enhanced Raman scattering (SERS) platform developed by our group, the pathogens can be differentiated on the basis of their SERS spectra which are believed to related to their surface chemical components. We collected the SERS spectra of ten pathogens:...
A color image splicing detection method based on gray level co-occurrence matrix (GLCM) of thresholded edge image of image chroma is proposed in this paper. Edge images are generated by subtracting horizontal, vertical, main and minor diagonal pixel values from current pixel values respectively and then thresholded with a predefined threshold T. The GLCMs of edge images along the four directions serve...
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