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Baclofen, a γ‐amino‐butyric‐acid (GABA)B receptor agonist, can reduce cue‐enhanced cocaine‐seeking in rats and attenuate cue‐evoked craving in cocaine addicts. However, baclofen also has sedative effects that might interfere with its efficacy in reducing cocaine's rewarding effects. The present study aimed at comparing the effects of baclofen with the GABAB‐receptor positive allosteric modulator GS39783...
Rationale There is evidence that serotonin2C (5-HT2C) receptors can modulate some behavioural effects of nicotine, but the generality of this action is not known. Objective To analyse the influence of the 5-HT2C agonist Ro-60-0175 on responses to nicotine in the five-choice serial reaction time task (5-CSRTT) and on its discriminative stimulus effect; these procedures constitute models for attention-enhancing...
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