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Several recent studies suggest functional and molecular interactions between striatal adenosine A2A and cannabinoid CB1 receptors. Here, we demonstrate that A2A receptors selectively modulate reinforcing effects of cannabinoids. We studied effects of A2A receptor blockade on the reinforcing effects of delta‐9‐tetrahydrocannabinol (THC) and the endogenous CB1 receptor ligand anandamide under a fixed‐ratio...
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