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We examined the clinical performance of contraceptive vaginal rings (rings) delivering Nestorone (NES) progestin and ethinyl estradiol (EE). Ring removal times were signaled by menstrual events. Bleeding patterns, adverse events, patterns of use and continuation rates were the principal parameters evaluated.In a two-stage 6-month trial, subjects were randomized to use rings releasing 50 μg/day of...
This trial tested the hypothesis that menstrually signaled use of contraceptive vaginal rings (“rings”) releasing low-dose combinations of Nestorone (NES) and ethinyl estradiol (EE) would reliably suppress luteal activity and ovulation, and prevent unintended pregnancy, while controlling the incidence of menstrual bleeding episodes and bleeding days.Nestorone/ethinyl estradiol rings releasing 50/10,...
The 19-nor derivatives of progesterone are referred to as ''pure'' progestational molecules as they bind almost exclusively to the progesterone receptor (PR) without interfering with receptors of other steroids. In this category is Nestorone ( R), which has strong progestational activity and antiovulatory potency with no androgenic or estrogenic activity in vivo. These properties make it highly...
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