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Appropriate regulation of mRNA translation is essential for growth and survival and the pathways that regulate mRNA translation have been highly conserved throughout eukaryotic evolution. Translation is controlled by a complex set of mechanisms acting at multiple levels, ranging from global protein synthesis to individual mRNAs. Recently, several mutations that perturb regulation of mRNA...
The target of rapamycin (TOR) kinase defines a highly conserved nutrient-response pathway that is known to modulate longevity in invertebrate organisms. Multiple mutations in this pathway that reduce TOR signaling have been reported to increase life span in different organisms, as has pharmacological inhibition of TOR. Multiple TOR-regulated processes are also known to play a role in longevity control,...
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