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Hintergrund Untersuchung des Zusammenhangs zwischen positiver Familienanamnese Demenz (jeweils Verwandte ersten und zweiten Grades) und ApoE-Polymorphismus bei Patienten mit frontotemporaler Demenz (FTD) mit Krankheitsbeginn bis zum 70. Lebensjahr. Material und Methoden 494 Demenzpatienten (73 FTD-Patienten) und 82 Kontrollen, bestehend aus den kognitiv gesunden Lebenspartnern. Neuropsychologische...
The large scale oscillation of insonified microbubbles (MBs) is considered to be the primary effect for sonoporation and thus enhances cell transfection in gene therapy. MB destruction on the other hand is suspected to lead to lower transfection rates. For future in vivo therapy, online acoustic monitoring could be used to identify these effects and to determine optimal pulse sequence parameters adaptively...
The success of the transportation of genes or drugs into cells via sonoporation strongly depends on the applied acoustic pressure. But especially in in vivo applications, locally deposited acoustic energy is unknown since anatomical structures like bones and the lung attenuate and reflect sound waves strongly. Therefore, the local acoustic pressure may not lie within the optimal range for sonoporation...
Support vector machines are applied to extract marker genes from various microarray data sets: breast cancer, leukemia and monocyte - macrophage differentiation to ease classification of related pathologies or characterize related gene regulation pathways.
In this study we focus on classification tasks and apply matrix factorization techniques like principal component analysis (PCA), independent component analysis (ICA) and non-negative matrix factorization ( NMF) to a microarray data set. The latter monitors the gene expression levels (GEL) of mononcytes and macrophages during and after differentiation. We show that these tools are able to identify...
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