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Melanoma is one of the most severe skin cancers, derived from melanocytes. Among various therapies for melanoma, adoptive immunotherapy using tumor‐infiltrating lymphocytes/chimeric antigen receptor‐T cells (TCs) is advanced in recent years; however, the efficacy is still limited, and major challenges remain in terms of safety and cell supply. To solve the issues of adoptive immunotherapy, we utilized...
Background
Type 1 interferons (IFNs), including IFN‐β, are widely used in adjuvant therapy for patients who undergo surgery for malignant melanoma to inhibit recurrence and in‐transit metastasis. The precise mechanisms underlying the tumor‐suppressive effects of IFN‐β on melanoma are not yet completely understood.
Objective
The purpose was to reveal the mechanisms underlying the tumor‐suppressive...
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