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Rationale 5-HT1A receptor knockout (1AKO) mice have a robust anxiety phenotype. Tissue-specific “rescue” strategies and electrophysiology have implicated a critical role for postsynaptic 5-HT1A receptors, particularly in the CA1 region of the hippocampus. Objectives In this study, we evaluated differences in membrane properties and synaptic activity in CA1 hippocampal pyramidal cells between 1AKOs...
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