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Pancreatic ductal adenocarcinoma (PDA) is one of the most prevalent types of cancer. Studies have shown that PDA treatment with IV administration of gemcitabine (GEM) is inhibited by excessive interstitium and connective tissue (stroma) surrounding the tumor. Ultrasound (US) irradiation combined with drug-loaded polylactic acid (PLA) microbubble contrast agents (MB) may circumvent this through targeted...
Studies have shown that treatment of pancreatic ductal adenocarcinoma (PDAC) with systemic administration of gemcitabine (GEM) is inhibited by excessive desmoplastic connective tissue surrounding the tumor. Ultrasound (US) insonification combined with drug-loaded poly lactic acid (PLA) microbubbles (MB) may circumvent this through targeted delivery to the tumor via increased permeability and lodging...
Reducing the number of features whilst maintaining an acceptable classification accuracy is a fundamental step in the process of constructing cancer predictive models. In this work, we introduce a novel hybrid (MI-LDA) feature selection approach for the diagnosis of ovarian cancer. This hybrid approach is embedded within a global optimization framework and offers a promising improvement on feature...
Objective
African‐Caribbean men in the United Kingdom in comparison with other ethnicities have the highest incidence rate of prostate cancer. Psychosocial aspects related to screening and presentation impact on men's behavior, with previous studies indicating a range of barriers. This study explores one such barrier, the digital rectal examination (DRE), due to its prominence within UK African‐Caribbean...
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