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Scope
Omega‐6 (n‐6) PUFA‐rich diets are generally considered obesogenic in rodents. Here, we examined how long‐term intake of a high‐fat/high‐sucrose (HF/HS) diet based on safflower oil affected metabolism, inflammation, and gut microbiota composition.
Methods and results
We fed male C57BL/6J mice a HF/HS diet based on safflower oil—rich in n‐6 PUFAs—or a low‐fat/low‐sucrose diet for 40 wk. Compared...
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