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Novel liver-specific nitric oxide (NO) releasing drugs with bile acid as both the NO carrier and targeting ligand were designed and synthesized by direct nitration of the hydroxyl group in bile acids or the 3-O-hydroxyl alkyl derivatives, with the intact 24-COOH being preserved for hepatocyte specific recognition. Preliminary biological evaluation revealed that oral administrated targeted conjugates...
A new ellagitannin, named bractin (1), had been isolated from the dried aerial part of Cleidion bracteosum. Its structure was determined based on various of spectral analysis.
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