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LAG-3 (CD223) is a cell surface molecule expressed on activated T cells (Huard et al. Immunogenetics 39:213–217, 1994), NK cells (Triebel et al. J Exp Med 171:1393–1405, 1990), B cells (Kisielow et al. Eur J Immunol 35:2081–2088, 2005), and plasmacytoid dendritic cells (Workman et al. J Immunol 182:1885–1891, 2009) that plays an important but incompletely understood role in the function of these lymphocyte...
BACKGROUNDThe CD8 T‐cell response to prostate and other cancers is often functionally diminished or absent. This may occur via deletion of tumor‐specific T cells, through acquisition of an anergic phenotype, or via active suppression mediated by another population of cells.
METHODSWe used a double transgenic model in which mice express CD8 T cells specific for a prostate/prostate cancer antigen to...
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