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To determine the role of the phospholipase D (PLD) pathway in injury and survival of alveolar epithelial cells, A549 cells were exposed to H 2 O 2 (500μM) which resulted in time-dependent injury and bi-phasic increase of PLD activity at 5min and at 3h, respectively. n-Butanol (0.5%) inhibited PLD activation, attenuated cell injury at 5min of H 2 O 2 exposure, but enhanced...
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