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Background The venom of predatory marine cone snails mainly contains a diverse array of unique bioactive peptides commonly referred to as conopeptides or conotoxins. These peptides have proven to be valuable pharmacological probes and potential drugs because of their high specificity and affinity to important ion channels, receptors and transporters of the nervous system. Most previous studies have...
To study the chemical constituents of the venom of Conus betulinus that collected from South China Sea. Gel chromatography and HPLC were applied to isolate toxins from the venom of Conus betulinus and a peptide toxin was obtained. Its chemical structure was characterized by mass spectrometry, amino acid analysis, N-terminal sequence and disulfide location. The structure was validated by comparison...
Cone snails are tropical marine mollusks that envenomate prey with a complex mixture of neuropharmacologically active compounds for the purpose of feeding and defence, each evolved to act in a highly specific manner on different parts of the nervous system. Here, we report the peptide purification, molecular cloning, chemical synthesis, and functional characterization of a structurally unique toxin...
O-superfamily conotoxins include several families that have diverse pharmacological activity on Na + , K + or Ca 2+ channels. These superfamily toxins have been mainly found in fish-hunting and mollusk-hunting Conus species. Here, we reported two novel O-superfamily conotoxins, vx6a and vx6b, purified from a worm-hunting cone snail, Conus vexillum. Though their cysteine framework...
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