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Background and Aims
Nuclear‐located covalently closed circular DNA (cccDNA) of hepatitis B virus (HBV) is a determining factor for HBV persistence and the key obstacle for a cure of chronic hepatitis B. However, it remains unclear whether and how the host immune system senses HBV cccDNA and its biological consequences.
Approach and Results
Here, we demonstrated that interferon‐inducible protein...
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