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BACKGROUND: Recently, basigin (BSG), which carries OK antigens on red blood cells (RBCs), was reported to be the receptor of the Plasmodium falciparum reticulocyte‐binding protein homolog 5 (PfRh5). BSG–PfRh5 is the only essential receptor–ligand pair in P. falciparum invasion that is known to date. However, the kind of OK/BSG polymorphism involved in the selection pressure caused by P. falciparum...
BACKGROUND: This study aimed to analyze the mutation spectrum of the JK‐null phenotype in the Chinese population. The JK gene encoding the Kidd blood group antigen protein and JK*A/JK*B polymorphism caused by a G‐to‐A mutation at nt838 are well described. However, the molecular basis of the JK‐null phenotype in Chinese populations remains unclear.
STUDY DESIGN AND METHODS: Sixteen unrelated JK‐null...
BACKGROUND: The D variant phenotypes are often categorized into weak D types and partial D types. Although the molecular basis underlying the partial D phenotype has been investigated in several races, data from Chinese populations are rare.
STUDY DESIGN AND METHODS: We collected partial D samples from 1,274,540 blood donors, as well as from sporadic patients in the Chinese population, over a 4‐year...
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