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Glimm et al. (2010) and Tamhane et al. (2010) studied the problem of testing a primary and a secondary endpoint, subject to a gatekeeping constraint, using a group sequential design (GSD) with looks. In this article, we greatly extend the previous results to multiple () looks. If the familywise error rate (FWER) is to be controlled at a preassigned level then it is clear that the primary...
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