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Rationale. Neurotoxic effects of 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) on the serotonin (5-HT) system have been described in animals and humans, but little is known about long-term effects of ecstasy use on mood. Objectives. To investigate short-term and long-term effects of ecstasy use on mood and its association with 5-HT neurotoxicity, dose, and gender in humans. Methods. Fifteen moderate...
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