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Thyrotropin-releasing hormone (TRH) decreases transcription of the Kv1.5 K + channel gene in GH 3 pituitary cells. Here, we examine whether TRH utilizes Gq activated phospholipase C, Gs or Gi to produce this response. We report that expression of constitutively active Gαq mimicked and occluded the TRH effect. In contrast, expression of activated Gα S or Gα i2 had...
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