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Purpose Different pharmacokinetic methods for [18F]FDDNP studies were evaluated using both simulations and clinical data. Procedures Methods included two-tissue reversible plasma (2T4k), simplified reference tissue input (SRTM), and a modified 2T4k models. The latter included an additional compartment for metabolites (2T1M). For plasma input models, binding potential, BPND, was obtained both directly...
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