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CDX2 is a homeobox transcription factor that works as a master gene in intestinal differentiation, both in the colon and in aberrant locations such as intestinal metaplasia (IM) of the stomach. Transgenic mice with Cdx2 expression in the stomach develop IM and Cdx2+/− mice develop hamartomatous polyps in the colon presenting gastric differentiation. We previously observed regulation of CDX2 by the...
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