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Genetic variations are always related to human diseases or susceptibility to therapies. Nucleic acid probes that precisely distinguish closely related sequences become an indispensable requisite both in research and clinical applications. Here, a Sequence‐guided DNA LOCalization for leaKless DNA detection (SeqLOCK) is introduced as a technique for DNA hybridization, where the intended targets carrying...
Intervertebral disc degeneration (IVDD) is a significant contributor to low back pain, characterized by excessive reactive oxygen species generation and inflammation‐induced pyroptosis. Unfortunately, there are currently no specific molecules or materials available to effectively delay IVDD. This study develops a multifunctional full name of PG@Cu nanoparticle network (PG@Cu). A designed pentapeptide,...
Intervertebral Disc Degeneration
In article number 2308167, Pooyan Makvandi, Yunlong Zhou, Aimin Wu, and co‐workers prepared a multifunctional metal polyphenol nanoparticle that exhibited the ability to escape lysosomal capture and effectively targeted mitochondria to scavenge excess reactive oxygen species. The results of in vitro and in vivo experiments showed that the nanoparticles retarded disc...
Low‐dimensional materials serving as photocatalysts favor providing abundant unsaturated active sites and shortening the charge transport distance, but the high surface energy readily causes the aggregation that limits their application. Herein, it is demonstrated that 2D covalent organic framework (COF) TpBD nanosheets are effective in the dispersion and stabilization of 0D Ni(OH)2. The COF precursor...