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The Trk family consists of three receptor tyrosine kinases, each of which can be activated by one or more of four neurotrophins—NGF, BDNF, NT3 and NT4. Neurotrophins mediate their multiple effects through a number of distinct intracellular signaling cascades regulating such diverse biological responses as cell survival, proliferation and differentiation in normal and neoplastic neuronal cells. Expression...
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