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To mimic natural extracellular matrix architecture, the poly (L-lactic acid) (PLLA) scaffolds loading icariin and icariin-2-hydroxypropyl-beta-cyclodextrin inclusion complex were prepared via phase separation, solvent replacement and freeze-drying. The morphologies of PLLA scaffolds were visualized with scanning electron microscopy, the icariin concentration and drug release in vitro were determined...
This study was aiming to investigate the fabrication and characterization of the porous chitosan/gelatin scaffold cross-linked with genipin (GP) which is widely used as a natural and non-toxic cross-linking agent. The chitosan/gelatin scaffold was prepared and cross-linked with 1% or 2%(w/w) genipin for 24 hours at 37degC, then pre-freezing for 48h at -20degC and -80degC before freeze drying. As a...
Biodegradable polymers have been widely used as scaffolding materials to regenerate new tissues. To mimic natural extracellular matrix architecture, a novel highly porous structure, which is a three-dimensional interconnected fibrous network with a fiber diameter ranging from 100 to 500 nm, has been created from poly (L-lactic acid) in this work. These fibrous matrices were prepared from the polymer...
In the present study, poly (D, L-lactic acid) (PDLLA) modified genipin-cross-linked chitosan/gelatin scaffolds loaded icariin were prepared. The scaffolds with genipin cross-linking were fabricated with lyophilization, and then were immersed into the 2.5%, 5.0%, and 7.5% PDLLA-dichloromethane solutions. Thus the PDLLA modified genipin-cross-linked scaffolds were obtained after evaporating the solvent...
In the present study, the functions of bovine chondrocytes on tetrandrine-loading poly (L-lactic acid) (PLLA) films were investigated in vitro. The surface characteristics of control PLLA and tetrandrine-loading PLLA films were examined by water contact angle measurement and electron spectroscopy for chemical analysis (ESCA). The contact angle indicated the change in hydrophilicity and the ESCA data...
PingYu capsule was a novel compound botanical drug, being composed of the extracts from Radix et Rhizoma Ginseng, Fructus Jujubae and Radix et Rhizoma Glycyrrhizae, which were the classical herbal medicines in China. Depression is one of psychological and/or physiological disorders. In the recent decades, depression affected the people's health seriously. This study was designed to demonstrate the...
The goal of this study was to evaluate the technological feasibility of delivering poorly water-soluble antibacterial agent using chitosan coated alginate/gelatin microspheres. The microspheres were prepared by an emulsification technique, characterized by Fourier transform infrared spectrophotometry (FT-IR), differential scanning calorimetry (DSC), scanning electron microscopy (SEM). Drug loading,...
The objective of this study was to investigate the efficiency of poly (L-lactic acid) (PLLA) surface modification with chitosan and gelatin. The properties of original PLLA films and modified PLLA films were investigated by water contact angle measurement and electron spectroscopy for chemical analysis (ESCA). The attachment and proliferation of bovine articular chondrocytes seeded on modified PLLA...
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