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Hypoxia and a marked increase in inflammatory cytokines are common hallmarks of intervertebral disc degeneration; these events disrupt the normal balance between extracellular matrix (ECM) degradation and synthesis in degenerative intervertebral discs. SIRT1, one of the NAD+‐dependent class III histone deacetylases, controls cellular processes and is regulated by hypoxia and inflammatory cytokines...
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