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Decreased activity of complex I (NAD:ubiquinone oxidoreductase) is the most frequent biochemical finding associated with the mutation at the base pair 3243 of the mitochondrial DNA. The mutation has been previously shown to lead to a defective translation. We hypothesized that due to an imperfect assembly of complex I subunits the substrate affinity of this enzyme may be lowered and this may be...
Decreased activity of complex I (NAD:ubiquinone oxidoreductase) is the most frequent biochemical finding associated with the mutation at the base pair 3243 of the mitochondrial DNA. The mutation has been previously shown to lead to a defective translation. We hypothesized that due to an imperfect assembly of complex I subunits the substrate affinity of this enzyme may be lowered and this may be counteracted...
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