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This study sought to investigate the role of secretory phospholipase A2 (sPLA2)-IIA in cardiovascular disease.Higher circulating levels of sPLA2-IIA mass or sPLA2 enzyme activity have been associated with increased risk of cardiovascular events. However, it is not clear if this association is causal. A recent phase III clinical trial of an sPLA2 inhibitor (varespladib) was stopped prematurely for...
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